Publications

Surgery

Head of Department:
Prof. Dr. med. Robert Grützmann, MBA

Selected publications

Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription.
Ubieta K, Garcia M, Grötsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D, Bozec A.
J Exp Med. 2017 Jul 3;214(7):2059-2071.

Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response.
Lehmann B, Biburger M, Brückner C, Ipsen-Escobedo A, Gordan S, Lehmann C, Voehringer D, Winkler T, Schaft N, Dudziak D, Sirbu H, Weber GF, Nimmerjahn F.
Science Immunology. 2017 Jan 06. Vol. 2, Issue 7, eaah6413

Pathogenic, immunologic, and clinical aspects of sepsis - update 2016.
Uhle F, Chousterman BG, Grützmann R, Brenner T, Weber GF.
Expert Rev Anti Infect Ther. 2016 Oct;14(10):917-27.

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. 
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK.
Nature Medicine. 2016 Aug;22(8):945-51.

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK.
Science. 2015 Mar 13;347(6227):1260-5.

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK.
J Exp Med. 2014 Jun 2;211(6):1243-56.

Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK.
Nat Med. 2013 Sep;19(9):1166-72.

Innate response activator B cells protect against microbial sepsis.
Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK.
Science. 2012 Feb 3;335(6068):597-601.

Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis.
Weber GF, Schlautkötter S, Kaiser-Moore S, Altmayr F, Holzmann B, Weighardt H.
Infect Immun. 2007 Apr;75(4):1690-7.

IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase.
Weber GF, Gaertner FC, Erl W, Janssen KP, Blechert B, Holzmann B, Weighardt H, Essler M.
J Immunol. 2006 Dec 1;177(11):8266-72.

 
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Summary