Original articles AMEC 2009-2012

Surgery

Head of Department:
Prof. Dr. med. Robert Grützmann, MBA

Bleiziffer O, Hammon M, Arkudas A, Taeger CD, Beier JP, Amann K, Naschberger E, Stürzl M, Horch RE, Kneser U. Guanylate-binding protein 1 expression from embryonal endothelial progenitor cells reduces blood vessel density and cellular apoptosis in an axially vascularised tissue-engineered construct. BMC Biotechnol. 2012 Dec 6;12:94. doi: 10.1186/1472-6750-12-94.

Langheinrich MC, Schellerer V, Perrakis A, Lohmüller C, Schildberg C, Naschberger E, Stürzl M, Hohenberger W, Croner RS. Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract. Int J Clin Exp Pathol. 2012;5(7):614-23. Epub 2012 Sep 5. Review.

Croner RS, Balzer K, Schellerer V, Müller V, Schlabrakowsi A, Stürzl M, Naschberger E, Lang W. Molecular characterization of peripheral arterial disease in proximal extremity arteries. J Surg Res. 2012 Dec;178(2):1046-58. doi: 10.1016/j.jss.2012.07.024. Epub 2012 Aug 3.

Capaldo CT, Beeman N, Hilgarth RS, Nava P, Louis NA, Naschberger E, Stürzl M, Parkos CA, Nusrat A. IFN-γ and TNF-α-induced GBP-1 inhibits epithelial cell proliferation through suppression of β-catenin/TCF signaling. Mucosal Immunol. 2012 Nov;5(6):681-90. doi: 10.1038/mi.2012.41. Epub 2012 Jun 13.

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell. 2012 Jul 10;22(1):91-105. doi: 10.1016/j.ccr.2012.05.023.

Syguda A, Bauer M, Benscheid U, Ostler N, Naschberger E, Ince S, Stürzl M, Herrmann C. Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helices. FEBS J. 2012 Jul;279(14):2544-54. doi: 10.1111/j.1742-4658.2012.08637.x. Epub 2012 Jun 15.

Hahn AS, Kaufmann JK, Wies E, Naschberger E, Panteleev-Ivlev J, Schmidt K, Holzer A, Schmidt M, Chen J, König S, Ensser A, Myoung J, Brockmeyer NH, Stürzl M, Fleckenstein B, Neipel F. The Ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi’s sarcoma-associated herpesvirus. Nat Med. 2012 Jun;18(6):961-6. doi: 10.1038/nm.2805.

Kuhn E, Naschberger E, Konrad A, Croner RS, Britzen-Laurent N, Jochmann R, Münstedt H, Stürzl M. A novel chip-based parallel transfection assay to evaluate paracrine cell interactions. Lab on a Chip. 2012 Apr 7;12(7):1363-72. doi: 10.1039/c2lc20724a. Epub 2012 Feb 22.

Jochmann R, Lorenz P, Chudasama P, Zietz C, Stürzl M, Konrad A. KSHV Paracrine Effects on Tumorigenesis. In: Herpes Viruses. 2011; ISBN 978-953-307-750-5.

Langheinrich MC, Schellerer VS, Oeckl K, Stürzl M, Naschberger E, Croner RS. Molecular Mechanisms of Lymphatic Metastasis. In: Colorectal Cancer / Book 1. 2011; ISBN 978-953-307-707-9; 285-98.

Britzen-Laurent N, Schellerer VS, Croner RS, Stürzl M, Naschberger E. Modulation of Tumor Angiogenesis by a Host Anti-Tumor Response in Colorectal Cancer. In: Colorectal Cancer / Book 1. 2011; ISBN 978-953-307-707-9.

Kühl A, Banning C, Marzi A, Votteler J, Steffen I, Bertram S, Glowacka I, Konrad A, Stürzl M, Guo JT, Schubert U, Feldmann H, Behrens G, Schindler M, Pöhlmann S. The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin. J Infect Dis. 11 Nov;204 Suppl 3:S850-60. doi: 10.1093/infdis/jir378.

Schellerer VS, Mueller-Bergh L, Merkel S, Zimmermann R, Weiss D, Schlabrakowski A, Naschberger E, Stürzl M, Hohenberger W, Croner RS. The clinical value of von Willebrand factor in colorectal carcinomas. Am J Transl Res. 2011;3(5):445-53. Epub 2011 Sep 23.

Prokosch HU, Ries M, Beyer A, Schwenk M, Seggewies C, Köpcke F, Mate S, Martin M, Bärthlein B, Beckmann MW, Stürzl M, Croner R, Wullich B, Ganslandt T, Bürkle T. IT Infrastructure Components to Support Clinical Care and Translational Research Projects in a Comprehensive Cancer Center. Stud Health Technol Inform. 2011;169:892-6.

Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF. Deletion of Kaposi's sarcoma herpesvirus FLICE inhibitory protein (vFLIP) from the viral genome compromises the activation of STAT-1 responsive cellular genes and spindle cell formation in endothelial cells. J Virol. 2011 Oct;85(19):10375-88. doi: 10.1128/JVI.00226-11. Epub 2011 Jul 27.

Serafin V, Persano L, Moserle L, Esposito G, Ghisi M, Curtarello M, Bonanno L, Masiero M, Ribatti D, Stürzl M, Naschberger E, Croner RS, Jubb AM, Harris AL, Koeppen H, Amadori A, Indraccolo S. Notch3 signalling promotes tumour growth in colorectal cancer. J Pathol. 2011 Aug;224(4):448-60. doi: 10.1002/path.2895. Epub 2011 May 19.

Naschberger E, Schellerer VS, Rau TT, Croner RS, Stürzl M. Isolation of endothelial cells from human tumors. Methods Mol Biol. 2011;731:209-18. doi: 10.1007/978-1-61779-080-5_18.

Distler JH, Akhmetshina A, Dees C, Jüngel A, Stürzl M, Gay S, Pisetsky DS, Schett G, Distler O. Induction of apoptosis in circulating angiogenic cells by microparticles. Arthritis Rheum. 2011 Jul;63(7):2067-77. doi: 10.1002/art.30361.

Naschberger E, Wenzel J, Kretz CC, Herrmann M, Stürzl M and Kuhn A. Increased Expression of Guanylate Binding Protein-1 in Lesional Skin of Patients with Cutaneous Lupus Erythematosus. Exp Dermatol. 2011 Feb;20(2):102-6. doi: 10.1111/j.1600-0625.2010.01160.x. Epub 2010 Dec 2.

Bleiziffer O, Hammon M, Naschberger E, Lipnik K, Arkudas A, Rath S, Pryymachuk G, Beier JP, Stürzl M, Horch RE, Kneser U. Endothelial Progenitor Cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix. J Cell Mol Med. 2011 Nov;15(11):2452-61. doi: 10.1111/j.1582-4934.2010.01247.x.

Britzen-Laurent N, Bauer M, Berton V, Fischer N, Syguda A, Reipschläger S, Naschberger E, Herrmann C, Stürzl M. Intracellular Trafficking of Guanylate-Binding Proteins Is Regulated by Heterodimerization in a Hierarchical Manner. PLoS ONE. 2010 Dec 7;5(12):e14246.

Konrad A, Jochmann R, Kuhn E, Naschberger E, Chudasama P, Stürzl M. Reverse transfected cell microarrays in infectious disease research. Methods Mol Biol. 2011;706:107-18.

Croner RS, Schellerer V, Demund H, Schildberg C, Papadopulos T, Naschberger E, Stürzl M, Matzel KE, Hohenberger W, Schlabrakowski A. One Step Nucleic Acid Amplification (OSNA) - a new method for lymph node staging in colorectal carcinomas. J Transl Med. 2010 Sep 6;8:83.

Hammon M, Herrmann M, Bleiziffer O, Pryymachuk G, Andreoli L, Munoz LE, Amann KU, Mondini M, Gariglio M, Airó P, Schellerer VS, Hatzopoulos AK, Horch RE, Kneser U, Stürzl M, Naschberger E. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J Cell Mol Med. 2011 Jul;15(7):1582-92. doi: 10.1111/j.1582-4934.2010.01146.x.

Lipnik K, Naschberger E, Gonin-Laurent N, Kodajova P, Petznek H, Rungaldier S, Ferrini S, Astigiano S, Stürzl M, Hohenadl C. The interferon gamma-induced human guanylate binding protein-1 inhibits mammary tumor growth in mice. Mol Med. 2010 May-Jun;16(5-6):177-87. Epub 2010 Feb 5.

Vöpel T, Syguda A, Britzen-Laurent N, Kunzelmann S, Lüdemann MB, Dovengerds C, Stürzl M, Herrmann C. Mechanism of GTBase-Activity-Induced Self-Assembly of Human Guanylate Binding Protein 1. J Mol Biol. 2010 Jul 2;400(1):63-70. Epub 2010 May 5.

Dragu A, Schnürer S, Surmann-Schmitt C, von der Mark K, Stürzl M, Unglaub F, Wolf MB, Leffler M, Beier JP, Kneser U, Horch RE. Gene expression analysis of ischemia and reperfusion in human microsurgical free muscle tissue transfer. J Cell Mol Med. 2011 Apr;15(4):983-93. doi: 10.1111/j.1582-4934.2010.01061.x.

Dragu A, Linke R, Kuwert T, Unglaub F, Kneser U, Stürzl M, Horch RE, Bach AD. Interesting image. Tc-99m sestamibi SPECT/CT as a new tool for monitoring perfusion and viability of buried perforator based free flaps in breast reconstruction after breast cancer. Clin Nucl Med. 2010 Jan;35(1):36-7.

Stürzl M, Konrad A, Alkharsah KR, Jochmann R, Thurau M, Marquardt G, Schulz TF. The contribution of systems biology and reverse genetics to the understanding of Kaposi's sarcoma-associated herpesvirus pathogenesis in endothelial cells. Thromb Haemost. 2009 Dec;102(6):1117-34.

Venalis P, Maurer B, Akhmetshina A, Busch N, Dees C, Stürzl M, Zwerina J, Jüngel A, Gay S, Schett G, Distler O, Distler JH. Lack of inhibititory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo. J Cell Mol Med. 2009 Oct;13(10):4185-91.

Demir R, Dimmler A, Naschberger E, Demir I, Papadopoulos T, Melling N, Sturzl M, Hohenberger W. Malignant progression of invasive tumour cells seen in hypoxia present an accumulation of beta-catenin in the nucleus at the tumour front. Exp Mol Pathol. 2009 Oct;87(2):109-16.

Demir R, Naschberger L, Demir I, Melling N, Dimmler A, Papadopoulus T, Stürzl M, Klein P, Hohenberger W. Hypoxia Generates a More Invasive Phenotype of Tumour Cells: An In Vivo Experimental Setup Based on the Chorioallantoic Membrane. Pathol Oncol Res. 2009 Sep;15(3):417-22.

Persano L, Moserle L, Esposito G, Bronte V, Barbieri V, Iafrate M, Gardiman MP, Larghero P, Pfeffer U, Naschberger E, Stürzl M, Indraccolo S, Amadori A. Interferon-alpha Counteracts the Angiogenic Switch and Reduces Tumor Cell Proliferation in a Spontaneous Model of Prostatic Cancer. Carcinogenesis. 2009 May;30(5):851-60.

Bleiziffer O, Horch RE, Hammon M, Arkudas A, Naschberger E, Rath S, Pryymachuk G, Beier JP, Hatzopoulos AK, Stürzl M, Kneser U. T17b Murine Embryonal Endothelial Progenitor Cells can be induced towards both proliferation and differentiation in a fibrin matrix. J Cell Mol Med. 2009 May;13(5):926-35.

Mischek D, Steinborn R, Petznek H, Bichler C, Zatloukal K, Stürzl M, Günzburg WH, Hohenadl C. Molecularly characterised xenograft tumour mouse models: valuable tools for evaluation of new therapeutic strategies for secondary liver cancers. J Biomed Biotechnol. 2009;2009:437284.

Jochmann R, Thurau M, Jung S, Hofmann C, Naschberger E, Kremmer E, Harrer T, Miller M, Schaft N, Stürzl M. O-linked N-Acetylglucosaminylation of Sp1 Inhibits the Human Immunodeficiency Virus Type-1 Promoter. J Virol. 2009 Apr;83(8):3704-18.

Konrad A, Wies E, Thurau M, Marquardt G, Naschberger E, Hentschel S, Jochmann R, Schulz TF, Erfle H, Brors B, Lausen B, Neipel F, Stürzl M. A systems biology approach to identify combination effects of HHV-8 genes on NF-{kappa}B activation. J Virol. 2009 Mar;83(6):2563-74.

Thurau M, Marquardt G, Gonin-Laurent N, Weinländer K, Naschberger E, Jochmann R, Alkharsah KR, Schulz TF, Thome M, Neipel F, Stürzl M. The Viral Inhibitor of Apoptosis vFLIP/K13 Protects Endothelial Cells against Superoxide-induced Cell Death. J Virol. 2009 Jan;83(2):598-611.

Hahn A, Birkmann A, Wies E, Dorer D, Mahr K, Stürzl M, Titgemeyer F, Neipel F. Kaposis Sarcoma Associated Herpesvirus gH/gL: Glycoprotein Export and Interaction with Cellular Receptors. J Virol. 2009 Jan;83(1):396-407.

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