Original articles AMEC 2013-2016

Surgery

Head of Department:
Prof. Dr. med. Robert Grützmann, MBA

Williamson SJ, Nicol SM, Stürzl M, Sabbah S, Hislop AD. Azidothymidine sensitizes primary effusion lymphoma cells to Kaposi Sarcoma-Associated Herpesvirus-Specific CD4+ T cell control and inhibits vIRF3 function. PLoS Pathog. 2016 Nov 28;12(11):e1006042. doi: 10.1371/journal.ppat.1006042. eCollection 2016 Nov.

Naschberger E, Liebl A, Schellerer VS, Schütz M, Britzen-Laurent N, Kölbel P, Schaal U, Haep L, Regensburger D, Wittmann T, Klein-Hitpass L, Rau TT, Dietel B, Méniel VS, Clarke AR, Merkel S, Croner RS, Hohenberger W, Stürzl M. Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. J Clin Invest. 2016 Nov 1;126(11):4187-4204. doi: 10.1172/JCI78260. Epub 2016 Oct 10.

Hervorgehoben durch: Research Highlight Artikel: Thomas H. CRC endothelial regulation. Nat Rev Gastroenterol Hepatol. 2016 Dec;13(12):682. doi: 10.1038/nrgastro.2016.180. Epub 2016 Oct 26.

Bonsignore L, Passelli K, Pelzer C, Perroud M, Konrad A, Thurau M, Stürzl M, Dai L, Trillo-Tinoco J, Del Valle L, Qin Z, Thome M. A role for MALT1 activity in Kaposi's sarcoma-associated herpesvirus latency and growth of primary effusion lymphoma. Leukemia. 2017 Mar;31(3):614-624. doi: 10.1038/leu.2016.239. Epub 2016 Aug 19.

Britzen-Laurent N, Herrmann C, Naschberger E, Croner RS, Stürzl M. Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases. World J Gastroenterol. Jul 28;22(28):6434-43. doi: 10.3748/wjg.v22.i28.6434. Review.

Kesselring R, Glaesner J, Hiergeist A, Naschberger E, Neumann H, Brunner SM, Wege AK, Seebauer C, Köhl G, Merkl S, Croner RS, Hackl C, Stürzl M, Neurath MF, Gessner A, Schlitt HJ, Geissler EK, Fichtner-Feigl S. IRAK-M expression in tumor cells supports colorectal cancer progression through reduction of antimicrobial defense and stabilization of STAT3. Cancer Cell. 2016 May 9;29(5):684-96. doi: 10.1016/j.ccell.2016.03.014. Epub 2016 Apr 14.

Croner RS, Sevim M, Metodiev MV, Jo P, Ghadimi M, Schellerer V, Brunner M, Geppert C, Rau T, Stürzl M, Naschberger E, Matzel KE, Hohenberger W, Lottspeich F, Kellermann J. Identification of predictive markers for response to neoadjuvant chemoradiation in rectal carcinomas by proteomic isotope cded protein label (ICPL) analysis. Int J Mol Sci. 2016 Feb 4;17(2):209. doi: 10.3390/ijms17020209.

Feiersinger F, Nolte E, Wach S, Rau TT, Vassos N, Geppert C, Konrad A, Merkel S, Taubert H, Stürzl M, Croner RS. MiRNA-21 expression decreases from primary tumors to liver metastases in colorectal carcinoma. PLoS One. 2016 Feb 4;11(2):e0148580. doi: 10.1371/journal.pone.0148580. eCollection 2016.

Murtadak V, Becker, C, Stürzl M. Cell death inhibition by KSHV. AGING. 2015 Oct;7(10):750-1.

Wu JJ, Li W, Shao Y, Avey D, Fu B, Gillen J, Hand T, Ma S, Liu X, Miley W, Konrad A, Neipel F, Stürzl M, Whitby D, Li H, Zhu F. Inhibition of cGAS DNA sensing by a herpesvirus virion protein. Cell Host Microbe. 2015 Sep 9;18(3):333-44. doi: 10.1016/j.chom.2015.07.015. Epub 2015 Aug 27.

Haep L, Britzen-Laurent N, Weber TG, Naschberger E, Schaefer A, Kremmer E, Foersch S, Vieth M, Scheuer W, Wirtz S, Waldner M, Stürzl M. Interferon gamma counteracts the angiogenic switch and induces vascular permeability in dextran sulfate sodium colitis in mice. Inflamm Bowel Dis. 2015 Oct;21(10):2360-71. doi: 10.1097/MIB.0000000000000490.

Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ. VEGFR2 signaling prevents colorectal cancer cell senescence to promote tumorigenesis in mice with colitis. Gastroenterology. 2015 Jul;149(1):177-189.e10. doi: 10.1053/j.gastro.2015.03.016. Epub 2015 Mar 19.

Lancrajan I, Schneider-Stock R, Naschberger E, Schellerer VS, Stürzl M, Enz R. Absolute quantification of DcR3 and GDF15 from human serum by LC-ESI MS. J Cell Mol Med. 2015 Jul;19(7):1656-71. doi: 10.1111/jcmm.12540. Epub 2015 Mar 30.

Kraus C, Rau TT, Lux P, Erlenbach-Wünsch K, Löhr S, Krumbiegel M, Thiel CT, Stöhr R, Agaimy A, Croner RS, Stürzl M, Hohenberger W, Hartmann A, Reis A. Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations. Int J Cancer. 2015 Mar 15;136(6):E559-68. doi: 10.1002/ijc.29149. Epub 2014 Aug 30.

Chudasama P, Konrad A, Jochmann R, Lausen B, Holz P, Naschberger E, Neipel F, Britzen-Laurent N, Stürzl M. Structural proteins of Kaposi’s sarcoma-associated herpesvirus antagonize p53-mediated apoptosis. Oncogene. 2015 Jan 29;34(5):639-49. doi: 10.1038/onc.2013.595. Epub 2014 Jan 27.

Hävemeier A, Gramolelli S, Pietrek M, Jochmann R, Stürzl M, Schulz TF. Activation of NF-κB by the Kaposi's sarcoma herpesvirus K15 protein involves recruitment of the NF-κB-inducing kinase, IκB kinases and phosphorylation of p65. J Virol. 2014 Nov;88(22):13161-72. doi: 10.1128/JVI.01766-14. Epub 2014 Sep 3.

Bussey KA, Reimer E, Todt H, Denker B, Gallo A, Konrad A, Ottinger M, Adler H, Stürzl M, Brune W, Brinkmann MM. The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response. J Virol. 2014 Aug;88 (16):9245-59. doi: 10.1128/JVI.00841-14. Epub 2014 Jun 4.

Croner RS, Stürzl M, Rau T, Metodieva G, Geppert CI, Naschberger E, Lausen B, Metodiev MV. Quantitative proteome profiling of lymph node positive vs. negative colorectal carcinomas at a depth of 9,000 unique gene products pinpoints MX1 as a marker for lymph node metastasis. Int J Cancer. 2014 Dec 15;135(12):2878-86. doi: 10.1002/ijc.28929. Epub 2014 May 12.

Gaus D, Kuhn E, Konrad A, Jochmann R, Chudasama P, Naschberger E, Stürzl M. Cell-based microarrays: recent advances for gene function analyses. Over-expression arrays – cell-based microarray review. 2014; ISBN 978-1-4939-0593-5.

Schauer C, Janko C, Munoz LE, Zhao Y, Kienhöfer D, Frey B, Lell M, Manger B, Rech J, Naschberger E, Holmdahl R, Krenn V, Harrer T, Jeremic I, Bilyy R, Schett G, Hoffmann M, Herrmann M. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nature Medicine. 2014 May;20(5):511-7. doi: 10.1038/nm.3547. Epub 2014 Apr 28.

Croner RS, Geppert CI, Bader FG, Nitsche U, Späth C, Rosenberg R, Zettl A, Matias-Guiu X, Tarragona J, Güller U, Stürzl M, Zuber M. Molecular staging of lymph node negative colon carcinomas by One-Step Nucleic Acid Amplification (OSNA) results in an upstaging of a quarter of patients in a prospective, European, multicenter study.  Br J Cancer. 2014  May 13;110(10):2544-50. doi: 10.1038/bjc.2014.170. Epub 2014 Apr 10.

Full F, Lengenfelder D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung JU, Stamminger T, Ensser A. Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity. PLoS Pathog. 2014 Jan;10(1):e1003863. doi: 10.1371/journal.ppat.1003863. Epub 2014 Jan 16.

Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, Saliba A, Eckerstorfer P, Britzen-Laurent N, Schütz G, Schmid JA, Zlabinger GJ, Naschberger E, Stürzl M, Stockinger H. Guanylate binding protein 1-mediated interaction of T Cell antigen receptor signaling with the cytoskeleton. J Immunol 2014 Jan 15;192(2):771-81. doi: 10.4049/jimmunol.1300377. Epub 2013 Dec 13.

Jochmann R, Holz P, Sticht H, Stürzl M. Validation of the reliability of computational O-GlcNAc prediction. Biochim Biophys Acta. 2014 Feb;1844(2):416-21. doi: 10.1016/j.bbapap.2013.12.002. Epub 2013 Dec 9.

Schellerer VS, Langheinrich M, Hohenberger W, Croner RS, Merkel S, Rau TT, Stürzl M, Naschberger E. Tumor-associated fibroblasts isolated from colorectal cancer tissues exhibit increased ICAM-1 expression and affinity for monocytes. Oncol Rep. 2014 Jan;31(1):255-61. doi: 10.3892/or.2013.2860. Epub 2013 Nov 20.

Ostler N, Britzen-Laurent N, Liebl A, Naschberger E, Lochnit G, Ostler M, Forster F, Kunzelmann P, Ince S, Supper V, Praefcke GJK, Schubert DW, Stockinger H, Herrmann C, Stürzl M. IFN-γ-induced guanylate binding protein-1 is a novel actin cytoskeleton remodeling factor. Mol Cell Biol. 2014 Jan;34(2):196-209. doi: 10.1128/MCB.00664-13. Epub 2013 Nov 4.

Vassos N, Rau T, Merkel S, Feiersinger F, Geppert CI, Stürzl M, Hohenberger W, Croner RS. Prognostic value of β1 integrin expression in colorectal liver metastases. Int J Clin Exp Patho. 2013 Dec 15;7(1):288-300.

Köpcke F, Lubgan D, Fietkau R, Scholler A, Nau C, Stürzl M, Croner R, Prokosch HU, Toddenroth D. Evaluating predictive modeling algorithms to assess patient eligibility for clinical trials from routine data. BMC Med Inform Decis Mak. 2013 Dec 9;13:134. doi: 10.1186/1472-6947-13-134.

Grenz S, Naschberger E, Britzen-Laurent N, Schaal U, Merkel S, Konrad A, Aigner M, Rau TT, Hartmann A, Croner RS, Hohenberger W, Stürzl M. IFN-gamma-driven intratumoral microenvironment exhibits superior prognostic effect as compared to an IFN-alpha-driven microenvironment in patients with colon carcinoma. Am J Pathol. 2013 Dec;183(6):1897-909. doi: 10.1016/j.ajpath.2013.08.025. Epub 2013 Oct 8.

Schaal U, Grenz S, Merkel S, Rau TT, Hadjihannas MV, Kremmer E, Chudasama P, Croner RS, Behrens J, Stürzl M, Naschberger E. Expression and localization of axin 2 in colorectal carcinoma and its clinical implication. Int J Colorectal Dis. 2013 Nov;28(11):1469-78. doi: 10.1007/s00384-013-1709-6. Epub 2013 May 24.

Ostalecki C, Konrad A, Thurau E, Schuler G, Croner RS, Pommer AJ, Stürzl M. Combined multi-gene analysis at the RNA and protein levels in single FFPE tissue sections. Exp Mol Pathol. 2013 Aug;95(1):1-6. doi: 10.1016/j.yexmp.2013.03.008. Epub 2013 Apr 9.

Jochmann R, Pfannstiel J, Chudasama P, Kuhn E, Konrad A, Stürzl M. O-GlcNAc transferase inhibits KSHV propagation and modifies replication relevant viral proteins as detected by systematic O-GlcNAcylation analysis. Glycobiology. 2013 Oct;23(10):1114-30. doi: 10.1093/glycob/cwt028. Epub 2013 Apr 11.

Stein MF, Lang S, Winkler TH, Deinzer A, Erber S, Nettelbeck DM, Naschberger E, Jochmann R, Stürzl M, Slany RK, Werner T, Steinkasserer A, Knippertz I. Multiple IRF- and NFkB-sites cooperate in mediating cell type- and maturation-specific activation of the human CD83 promoter in dendritic cells. Mol Cell Biol. 2013 Apr;33(7):1331-44. doi: 10.1128/MCB.01051-12. Epub 2013 Jan 22.

Britzen-Laurent N, Lipnik K, Ocker M, Naschberger E, Schellerer VS, Croner RS, Vieth M, Waldner M, Steinberg P, Hohenadl C, Stürzl M. GBP-1 acts as a tumor suppressor in colorectal cancer cells. Carcinogenesis. 2013 Jan;34(1):153-62. doi: 10.1093/carcin/bgs310. Epub 2012 Oct 6.

Stürzl M, Gaus D, Dirks WG, Ganem D, Jochmann R. The Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line. Int J Cancer. 2013 Apr 15;132(8):1954-8. doi: 10.1002/ijc.27849. Epub 2012 Oct 12.

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