Original articles AMEC 2017-2019

Surgery

Head of Department:
Prof. Dr. med. Robert Grützmann, MBA

Gründner J, Schwachhofer T, Sippl P, Wolf N, Erpenbeck M, Gulden C, Kapsner LA, Zierk J, Mate S, Stürzl M, Croner R, Prokosch HU, Toddenroth D. KETOS: Clinical decision support and machine learning as a service - A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services. PLoS One. 2019 Oct 3;14(10):e0223010. doi: 10.1371/journal.pone.0223010. eCollection 2019.

Langer V, Vivi E, Regensburger D, Winkler TH, Waldner MJ, Rath T, Schmid B, Skottke L, Lee S, Jeon NL, Wohlfahrt T, Kramer V, Tripal P, Schumann M, Kersting S, Handtrack C, Geppert CI, Suchowski K, Adams RH, Becker C, Ramming A, Naschberger E, Britzen-Laurent N, Stürzl M. IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption. J Clin Invest. 2019 Sep 30. pii: 124884. doi: 10.1172/JCI124884. [Epub ahead of print]

Bardenbacher M, Ruder B, Britzen-Laurent N, Schmid B, Waldner M, Naschberger E, Scharl M, Müller W, Günther C, Becker C, Stürzl M, Tripal P. Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids. Stem Cell Res. 2019 Mar;35:101383. doi: 10.1016/j.scr.2019.101383. Epub 2019 Feb 7.

Wohlfahrt T, Rauber S, Uebe S, Luber M, Soare A, Ekici A, Weber S, Matei AE, Chen CW, Maier C, Karouzakis E, Kiener HP, Pachera E, Dees C, Beyer C, Daniel C, Gelse K, Kremer AE, Naschberger E, Stürzl M, Butter F, Sticherling M, Finotto S, Kreuter A, Kaplan MH, Jüngel A, Gay S, Nutt SL, Boykin DW, Poon GMK, Distler O, Schett G, Distler JHW, Ramming A. PU.1 controls fibroblast polarization and tissue fibrosis. Nature. 2019 Feb;566(7744):344-349. doi: 10.1038/s41586-019-0896-x. Epub 2019 Jan 30.

Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M. β6 -Integrin serves as a novel serum tumor marker for colorectal carcinoma. Int J Cancer. 2019 Aug 1;145(3):678-685. doi: 10.1002/ijc.32137. Epub 2019 Jan 29.

Schellerer VS, Langheinrich MC, Zver V, Grützmann R, Stürzl M, Gefeller O, Naschberger E, Merkel S. Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma. Int J Colorectal Dis. 2019 Feb;34(2):309-317. doi: 10.1007/s00384-018-3198-0. Epub 2018 Nov 23.

Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU. Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12.

Ellmann S, Langer V, Britzen-Laurent N, Hildner K, Huber C, Tripal P, Seyler L, Waldner M, Uder M, Stürzl M, Bäuerle T. Application of machine learning algorithms for multiparametric MRI-based evaluation of murine colitis. PLoS One. 2018 Oct 26;13(10):e0206576. doi: 10.1371/journal.pone.0206576. eCollection 2018.

Unterer B, Wiesmann V, Gunasekaran M, Sticht H, Tenkerian C, Behrens J, Leone M, Engel FB, Britzen-Laurent N, Naschberger E, Wittenberg T, Stürzl M. IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD. Biochem J. 2018 Sep 25;475(18):2955-2967. doi: 10.1042/BCJ20180123.

Ruder B, Murtadak V, Stürzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C. Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells. Mucosal Immunol. 2018 Nov;11(6):1621-1629. doi: 10.1038/s41385-018-0068-6. Epub 2018 Aug 13.

Czegley C, Gillmann C, Schauer C, Seyler L, Reinwald C, Hahn M, Uder M, Jochmann K, Naschberger E, Stock M, Schett G, Bäuerle T, Hoffmann MH. A model of chronic enthesitis and new bone formation characterized by multimodal Imaging. Dis Model Mech. 2018 Aug 30;11(9). pii: dmm034041. doi: 10.1242/dmm.034041.

Gründner J, Prokosch HU, Stürzl M, Croner R, Christoph J, Toddenroth D. Predicting Clinical Outcomes in Colorectal Cancer Using Machine Learning. Stud Health Technol Inform. 2018;247:101-105.

Naschberger E, Regensburger D, Tenkerian C, Langheinrich M, Engel FB, Geppert C, Hartmann A, Grützmann R, Schellerer VS, Stürzl M. Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol. J. Vis. Exp. 2018 Apr 4;(134). doi: 10.3791/57400.

May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting Inflammation.  J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16.

Hecht M, Harrer T, Körber V, Sarpong EO, Moser F, Fiebig N, Schwegler M, Stürzl M, Fietkau R, Distel LV. Cytotoxic effect of Efavirenz in BxPC-3 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation. Oncol Lett. 2018 Feb;15(2):1728-1736. doi: 10.3892/ol.2017.7523. Epub 2017 Dec 5.

Christoph J, Knell C, Bosserhoff A, Naschberger E, Stürzl M, Rübner M, Seuss H, Ruh M, Prokosch HU, Sedlmayr B. Usability and Suitability of the Omics-Integrating Analysis Platform tranSMART for Translational Research and Education. Appl Clin Inform. 2017 Oct;8(4):1173-1183. doi: 10.4338/ACI-2017-05-RA-0085. Epub 2017 Dec 21.

López-Posadas R, Stürzl M, Atreya I, Neurath MF, Britzen-Laurent N. Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation. Front Immunol. 2017 Oct 5;8:1240. doi: 10.3389/fimmu.2017.01240. eCollection 2017. Review.

Steiner D, Köhn K, Beier JP, Stürzl M, Horch R, Arkudas A. Cocultivation of Mesenchymal Stem Cells and Endothelial Progenitor Cells Reveals Antiapoptotic and Proangiogenic Effects. Cells Tissues Organs. 2017;204(5-6):218-227. doi: 10.1159/000478654. Epub 2017 Jul 27.

Shydlovskyi S, Zienert AY, Ince S, Dovengerds C, Hohendahl A, Dargazanli JM, Blum A, Günther SD, Kladt N, Stürzl M, Schauss AC, Kutsch M, Roux A, Praefcke GJK, Herrmann C. Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5559-E5568. doi: 10.1073/pnas.1620959114. Epub 2017 Jun 23.

Brüggemann C, Kirchberger MC, Goldinger SM, Weide B, Konrad A, Erdmann M, Schadendorf D, Croner RS, Krähenbühl L, Kähler KC, Hafner C, Leisgang W, Kiesewetter F, Dummer R, Schuler G, Stürzl M, Heinzerling L. Predictive value of PD-L1 based on mRNA level in the treatment of stage IV melanoma with ipilimumab. J Cancer Res Clin Oncol. 2017 Oct;143(10):1977-1984. doi: 10.1007/s00432-017-2450-2. Epub 2017 Jun 14.

Christoph J, Knell C, Naschberger E, Stürzl M, Maier C, Prokosch HU, Sedlmayr M. Two Years of tranSMART in a University Hospital for Translational Research and Education. Stud Health Technol Inform. 2017;236:70-79.

He GW, Günther C, Thonn V, Yu YQ, Martini E, Buchen B, Neurath MF, Stürzl M, Becker C. Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med. 2017 Jun 5;214(6):1655-1662. doi: 10.1084/jem.20160442. Epub 2017 May 5.

Suchowski K, Pöschinger T, Rehemtulla A, Stürzl M, Scheuer W. Noninvasive Bioluminescence Imaging of AKT Kinase Activity in Subcutaneous and Orthotopic NSCLC Xenografts: Correlation of AKT Activity with Tumor Growth Kinetics. Neoplasia. 2017 Apr;19(4):310-320. doi: 10.1016/j.neo.2017.02.005. Epub 2017 Mar 9.

Schicht M, Hesse K, Schröder H, Naschberger E, Lamprecht W, Garreis F, Paulsen FP, Bräuer L. Efficacy of aflibercept (EYLEA®) on inhibition of human VEGF in vitro. Ann Anat. 2017 May;211:135-139. doi: 10.1016/j.aanat.2017.02.005. Epub 2017 Mar 7.

Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Stürzl M, Britzen-Laurent N. Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity. J Cell Mol Med. 2017 Sep;21(9):1954-1966. doi: 10.1111/jcmm.13116. Epub 2017 Mar 8.