Molecular and Experimental Surgery

Surgery

Head of Department:
Prof. Dr. med. Robert Grützmann, MBA

Head: Prof. Dr. Dr. Michael Stürzl

The Division of Molecular and Experimental Surgery is a basic research unit in the Department of Surgery. In the focus of our research is the regulation of blood vessel function in inflammatory and infectious diseases.

Hypotheses and goals of our research:

Endothelial cells have multiple tasks in inflammation. They regulate the migration of leukocytes from the blood into the tissues (extravasation) and they form new vessels in order to increase the surface for the extravasation of immune cells. Many different factors with partly opposite activities are involved in inflammation-associated endothelial cell activation. Our goal is to map the temporal and spatial appearance and to elucidate the molecular regulation of the different endothelial cell activation phenotypes in inflammatory processes. This will provide new insights in the dynamic regulation of blood vessel activity and novel targets for the molecular therapy of inflammatory diseases.

The interaction of surgeons with molecular biologists, cell biologists and chemists fosters the development of new and clinically relevant research strategies. At present the division consists of 4 postdoctoral scientists, 5 PhD students, 5 technicians and 3 guest surgeons. The close interaction with the department of surgery is a specific strength of our research. Mutual educational programs introducing biologists to surgery and surgeons to molecular biology are a key strategy to support clinically relevant research and translation from bench to bedside.

From "Bench" to "Bedside"