Selected publications

Discrimination of pancreato-biliary cancer and pancreatitis by non-invasive liquid biopsy.
Hartwig C, Müller J, Klett H, Kouhestani D, Mittelstädt A, Anthuber A, David P, Brunner M, Jacobsen A, Glanz K, Swierzy I, Roßdeutsch L, Klösch B, Grützmann R, Wittenberger T, Sohn K, Weber GF.
Molecular Cancer. 2024 Feb 2;23(1):28

IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils.
Bénard A, Mittelstädt A, Klösch B, Glanz K, Müller J, Schoen J, Nüse B, Brunner M, Naschberger E, Stürzl M, Mattner J, Muñoz LE, Sohn K, Grützmann R, Weber GF.
Cell Reports. 2023 Jun 27;42(6):112637.

Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease- From Early Cancer Detection to Individualized Cancer Treatment.
David P, Mittelstädt A, Kouhestani D, Anthuber A, Kahlert C, Sohn K, Weber GF.
Cancers (Basel). 2023 Mar 23;15(7):1924.

Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming.
Bénard A, Hansen FJ, Uhle F, Klösch B, Czubayko F, Mittelstädt A, Jacobsen A, David P, Podolska MJ, Anthuber A, Swierzy I, Schaack D, Mühl-Zürbes P, Steinkasserer A, Weyand M, Weigand MA, Brenner T, Krautz C, Grützmann R, Weber GF.
Front Immunol. 2023 Feb 22;14:1140630.

Circulating Monocytes Serve as Novel Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma Patients.
Hansen FJ, David P, Akram M, Knoedler S, Mittelstädt A, Merkel S, Podolska MJ, Swierzy I, Roßdeutsch L, Klösch B, Kouhestani D, Anthuber A, Bénard A, Brunner M, Krautz C, Grützmann R, Weber GF.
Cancers (Basel). 2023 Jan 5;15(2):363

Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing.
Cho YK, Kim H, Bénard A, Woo HK, Czubayko F, David P, Hansen FJ, Lee JI, Park JH, Schneck E, Weber GF, Shin IS, Lee H.
Science Advances. 2022 Sep 23;8(38):eabq4022.

Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer.
Hansen FJ, Wu Z, David P, Mittelstädt A, Jacobsen A, Podolska MJ, Ubieta K, Brunner M, Kouhestani D, Swierzy I, Roßdeutsch L, Klösch B, Kutschick I, Merkel S, Denz A, Weber K, Geppert C, Grützmann R, Bénard A, Weber GF.
Int J Mol Sci. 2022 May 5;23(9):5163.

Pleural Resident Macrophages and Pleural IRA B Cells Promote Efficient Immunity Against Pneumonia by Inducing Early Pleural Space Inflammation.
Bénard A, Podolska MJ, Czubayko F, Kutschick I, Klösch B, Jacobsen A, Naschberger E, Brunner M, Krautz C, Trufa DI, Sirbu H, Lang R, Grützmann R, Weber GF.
Front Immunol. 2022 Apr 14;13:821480.

An overview of proteomic methods for the study of ‘cytokine storms’.
David P, Hansen FJ, Bhat A, Weber GF.
Expert Rev Proteomics. 2021 Feb; 18(2):83-91.

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Bénard A, Jacobsen A, Brunner M, Krautz C, Klösch B, Swierzy I, Naschberger E, Podolska MJ, Kouhestani D, David P, Birkholz T, Castellanos I, Trufa D, Sirbu H, Vetter M, Kremer AE, Hildner K, Hecker A, Edinger F, Tenbusch M, Mühl-Zürbes P, Steinkasserer A, Richter E, Streeck H, Berger MM, Brenner T, Weigand MA, Swirski FK, Schett G, Grützmann R, Weber GF.
Nat Commun. 2021 Feb 18;12(1):1112.

Upregulation of CD20 Positive B-Cells and B-Cell Aggregates in the Tumor Infiltration Zone is Associated with Better Survival of Patients with Pancreatic Ductal Adenocarcinoma.
Brunner M, Maier K, Rümmele P, Jacobsen A, Merkel S, Bénard A, Krautz C, Kersting S, Grützmann R, Weber GF.
Int J Mol Sci. 2020 Mar 5;21(5):1779.

The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection.
Fernandes VE, Ercoli G, Bénard A, Brandl C, Fahnenstiel H, Müller-Winkler J, Weber GF, Denny P, Nitschke L, Andrew PW.
PLoS Pathog. 2020 Apr 23;16(4).

Gata6(+) pericardial cavity macrophages relocate to the injured heart and prevent cardiac fibrosis.
Deniset JF, Belke D, Lee WY, Jorch SK, Deppermann C, Hassanabad AF, Turnbull JD, Teng G, Rozich I, Hudspeth K, Kanno Y, Brooks SR, Hadjantonakis AK, O'Shea JJ, Weber GF, Fedak PWM, Kubes P.
Immunity. 2019 Jul 16;51(1):131-140.

Influence of body mass index on long-term outcome in patients with rectal cancer-A single centre experience.
Kalb M, Langheinrich MC, Merkel S, Krautz C, Brunner M, Bénard A, Weber K, Pilarsky C, Grützmann R, Weber GF.
Cancers (Basel). 2019 Apr 30;11(5).

The Effect of GPRC5a on the proliferation, migration ability, chemotherapy resistance, and phosphorylation of GSK-3β in pancreatic cancer.
Liu B, Yang H, Pilarsky C, Weber GF.
Int J Mol Sci. 2018 Jun 26;19(7).

Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis - A meta-analysis.
Krautz C, Maier SL, Brunner M, Langheinrich M, Giamarellos-Bourboulis EJ, Gogos C, Armaganidis A, Kunath F, Grützmann R, Weber GF.
J Crit Care. 2018 Jun;45:71-75.

Integrated biosensor for rapid and point-of-care sepsis diagnosis.
Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H.
ACS Nano. 2018 Apr 24;12(4):3378-3384.

B Cells producing type I IFN modulate macrophage polarization in tuberculosis.
Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D.
Am J Respir Crit Care Med. 2018 Mar 15;197(6):801-813.

Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription.
Ubieta K, Garcia M, Grötsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D, Bozec A.
J Exp Med. 2017 Jul 3;214(7):2059-2071.

Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response.
Lehmann B, Biburger M, Brückner C, Ipsen-Escobedo A, Gordan S, Lehmann C, Voehringer D, Winkler T, Schaft N, Dudziak D, Sirbu H, Weber GF, Nimmerjahn F.
Science Immunology. 2017 Jan 06. Vol. 2, Issue 7, eaah6413

Pathogenic, immunologic, and clinical aspects of sepsis - update 2016.
Uhle F, Chousterman BG, Grützmann R, Brenner T, Weber GF.
Expert Rev Anti Infect Ther. 2016 Oct;14(10):917-27.

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. 
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK.
Nature Medicine. 2016 Aug;22(8):945-51.

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK.
Science. 2015 Mar 13;347(6227):1260-5.

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.
Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK.
J Exp Med. 2014 Jun 2;211(6):1243-56.

Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK.
Nat Med. 2013 Sep;19(9):1166-72.

Innate response activator B cells protect against microbial sepsis.
Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK.
Science. 2012 Feb 3;335(6068):597-601.

Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis.
Weber GF, Schlautkötter S, Kaiser-Moore S, Altmayr F, Holzmann B, Weighardt H.
Infect Immun. 2007 Apr;75(4):1690-7.

IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase.
Weber GF, Gaertner FC, Erl W, Janssen KP, Blechert B, Holzmann B, Weighardt H, Essler M.
J Immunol. 2006 Dec 1;177(11):8266-72.