Original articles AMEC 1997-2000


Head of Department:
Prof. Dr. med. Robert Grützmann, MBA

Sgadari C, Toschi E, Palladino C, Barillari G, Carlei D, Cereseto A, Ciccolella C, Yarchoan R, Monini P, Stürzl M, Ensoli B.Mechanism of paclitaxel activity in Kaposi's sarcoma. J Immunol. 2000 Jul 1;165(1):509-17.

Ensoli B, Stürzl M, Monini P.Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma. Semin Cancer Biol. 2000 Oct;10(5):367-81. Review.

Weninger W, Partanen TA, Breiteneder-Geleff S, Mayer C, Kowalski H, Mildner M, Pammer J, Stürzl M, Kerjaschki D, Alitalo K, Tschachler E.Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. Lab Invest. 1999 Feb;79(2):243-51.

Stürzl M, Ensoli B.Big but weak: how many pathogenic genes does human herpesvirus-8 need to cause Kaposi's sarcoma? Int J Oncol. 1999 Feb;14(2):287-9. Review.

Stürzl M, Wunderlich A, Ascherl G, Hohenadl C, Monini P, Zietz C, Browning PJ, Neipel F, Biberfeld P, Ensoli B.Human herpesvirus-8 (HHV-8) gene expression in Kaposi's sarcoma (KS) primary lesions: an in situ hybridization study. Leukemia. 1999 Apr;13 Suppl 1:S110-2.

Stürzl M, Hohenadl C, Zietz C, Castanos-Velez E, Wunderlich A, Ascherl G, Biberfeld P, Monini P, Browning PJ, Ensoli B.Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells. J Natl Cancer Inst. 1999 Oct 20;91(20):1725-33.

Monini P, Carlini F, Stürzl M, Rimessi P, Superti F, Franco M, Melucci-Vigo G, Cafaro A, Goletti D, Sgadari C, Butto' S, Leone P, Chiozzini C, Barresi C, Tinari A, Bonaccorsi A, Capobianchi MR, Giuliani M, di Carlo A, Andreoni M, Rezza G, Ensoli B.Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells. J Virol. 1999 May;73(5):4029-41.

Monini P, Colombini S, Stürzl M, Goletti D, Cafaro A, Sgadari C, Buttò S, Franco M, Leone P, Fais S, Leone P, Melucci-Vigo G, Chiozzini C, Carlini F, Ascherl G, Cornali E, Zietz C, Ramazzotti E, Ensoli F, Andreoni M, Pezzotti P, Rezza G, Yarchoan R, Gallo RC, Ensoli B.Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood. 1999 Jun 15;93(12):4044-58.

Hohenadl C, Germaier H, Walchner M, Hagenhofer M, Herrmann M, Stürzl M, Kind P, Hehlmann R, Erfle V, Leib-Mösch C.Transcriptional activation of endogenous retroviral sequences in human epidermal keratinocytes by UVB irradiation. J Invest Dermatol. 1999 Oct;113(4):587-94.

Fiorelli V, Barillari G, Toschi E, Sgadari C, Monini P, Stürzl M, Ensoli B.IFN-gamma induces endothelial cells to proliferate and to invade the extracellular matrix in response to the HIV-1 Tat protein: implications for AIDS-Kaposi's sarcoma pathogenesis. J Immunol. 1999 Jan 15;162(2):1165-70.

Ensoli B, Stürzl M.HHV-8 and multistep tumorigenesis. Trends Microbiol. 1999 Aug;7(8):310-2.

Brockmeyer NH, Willers CP, Anders S, Mertins L, Rockstroh JK, Stürzl M.Cytokine profile of HIV-positive Kaposi's sarcoma derived cells in vitro. Eur J Med Res. 1999 Mar 26;4(3):95-100.

Barillari G, Sgadari C, Fiorelli V, Samaniego F, Colombini S, Manzari V, Modesti A, Nair BC, Cafaro A, Stürzl M, Ensoli B.The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. Blood. 1999 Jul 15;94(2):663-72.

Barillari G, Sgadari C, Palladino C, Gendelman R, Caputo A, Morris CB, Nair BC, Markham P, Nel A, Stürzl M, Ensoli B.Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. J Immunol. 1999 Aug 15;163(4):1929-35.

Ascherl G, Hohenadl C, Schatz O, Shumay E, Bogner J, Eckhart L, Tschachler E, Monini P, Ensoli B, Stürzl M.Infection with human immunodeficiency virus-1 increases expression of vascular endothelial cell growth factor in T cells: implications for acquired immunodeficiency syndrome-associated vasculopathy. Blood. 1999 Jun 15;93(12):4232-41.

Ascherl G, Hohenadl C, Monini P, Zietz C, Browning PJ, Ensoli B, Stürzl M.Expression of human herpesvirus-8 (HHV-8) encoded pathogenic genes in Kaposi's sarcoma (KS) primary lesions. Adv Enzyme Regul. 1999;39:331-9.

Zietz C, Rössle M, Haas C, Sendelhofert A, Hirschmann A, Stürzl M, Löhrs U.MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Am J Pathol. 1998 Nov;153(5):1425-33.

Weninger W, Rendl M, Pammer J, Mildner M, Tschugguel W, Schneeberger C, Stürzl M, Tschachler E.Nitric oxide synthases in Kaposi's sarcoma are expressed predominantly by vessels and tissue macrophages. Lab Invest. 1998 Aug;78(8):949-55.

Stürzl M, Ascherl G, Blasig C, Opalenik SR, Ensoli B, Browning PJ.Expression of the human herpesvirus 8-encoded viral macrophage inflammatory protein-1 gene in Kaposi's sarcoma lesions. AIDS. 1998 Jun 18;12(9):1105-6.

Ensoli B, Stürzl M. Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agents. Cytokine Growth Factor Rev. 1998 Mar;9(1):63-83. Review

Biberfeld P, Ensoli B, Stürzl M, Schulz TF. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and HIV in pathogenesis of Kaposi's sarcoma. Curr Opin Infect Dis. 1998 Apr;11(2):97-105.

Stürzl M, Blasig C, Schreier A, Neipel F, Hohenadl C, Cornali E, Ascherl G, Esser S, Brockmeyer NH, Ekman M, Kaaya EE, Tschachler E, Biberfeld P.Expression of HHV-8 latency-associated T0.7 RNA in spindle cells and endothelial cells of AIDS-associated, classical and African Kaposi's sarcoma. Int J Cancer. 1997 Jul 3;72(1):68-71

Lang ME, Lottersberger C, Roth B, Böck G, Recheis H, Sgonc R, Stürzl M, Albini A, Tschachler E, Zangerle R, Donini S, Feichtinger H, Schwarz S.Induction of apoptosis in Kaposi's sarcoma spindle cell cultures by the subunits of human chorionic gonadotropin. AIDS. 1997 Sep;11(11):1333-40.

Davis MA, Stürzl MA, Blasig C, Schreier A, Guo HG, Reitz M, Opalenik SR, Browning PJ.Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells. J Natl Cancer Inst. 1997 Dec 17;89(24):1868-74.

Blasig C, Zietz C, Haar B, Neipel F, Esser S, Brockmeyer NH, Tschachler E, Colombini S, Ensoli B, Stürzl M.Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus 8. J Virol. 1997 Oct;71(10):7963-8.

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